Vasculitis is an autoimmune disease in which the body comes under attack from its own immune system, especially neutrophils, and in some cases it is also caused by reactions to medicines. It is a term for a group of rare diseases that are characterized by a condition that destroys blood vessels through inflammation. It can range from mild to life threatening and short term to long term. Vasculitis is caused by leukocyte migration and can affect arteries and veins in the body. It is found in both sexes and people of all ages. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a type of vasculitis. AAV is a group of three diseases including eosinophilic granulomatosis with polyangiitis, granulomatosis with polyangiitis, and microscopic polyangiitis.
AAV can affect small and medium blood vessels including arteries, veins, and capillaries in the body. It can cause poor blood flow to organs such as lungs, kidneys, nerves, and skin. AAV causes inflammation of blood vessels as it blocks or closes the path for blood flow, which can lead to aneurysms. The symptoms of vasculitis include shortness of breath, reddish spots on the skin, numbness, and sores. Vasculitis of the kidneys may produce no symptoms at first. However, it can lead to a serious condition. Vasculitis can be treated with immunosuppressive drugs, and its early detection and treatment can prevent permanent damage. The primary treatment for vasculitis includes the use of glucocorticoids. The dosage and the length of the treatment depends on the severity of the disease, history, and condition of the patient.
Rise in incidences of metabolic disorders and circulatory diseases and changing lifestyle are likely to increase the prevelance of this disease, driving the ANCA associated diseases/vasculitis market. However, lack of awareness is likely to restrain the ANCA Associated Diseases/Vasculitis market in the near future.
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The treatment of AAV is divided into two phases. The first phase of treatment is induction of remission and the second phase of treatment is maintenance. The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treatment market can be segmented based on route of administration of drug, distribution channel, and region. Based on the route of administration of drug, the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treatment market can be classified into parenteral, oral, nasal, and topical. The parenteral route segment accounts for a dominant share of the ANCA Associated Diseases/Vasculitis market due to higher availability and stability of the drug in the injectable form and immediate response. In terms of distribution channel, the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treatment market can be categorized into retail store, pharmacy, and e-commerce. The e-commerce segment is expected to account for a prominent market share by 2025 due to user convenience and increase in awareness about self-medication.
Based on region, the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) market can be split into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominates the ANCA Associated Diseases/Vasculitis market owing to increased awareness and high incidences of circulatory diseases and changing lifestyle. Europe is also a prominent region of the market due to advancement in health care technologies in the region. In addition, Asia Pacific is a rapidly expanding region of the Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treatment market because of changing lifestyle, rise in population following an urban lifestyle, and significant expansion in the economy of this region.
Some of the key players engaged in developing vasculitis therapeutics ANCA Associated Diseases/Vasculitismarket are Novartis AG, GlaxoSmithKline plc, F. Hoffmann-La Roche Ltd., RNL BIO Co., Ltd., Human Genome Sciences, Inc.¸ Johnson & Johnson’s, and Genentech, Inc. among others.