Global DNA and RNA Probes Market: Snapshot
Single-stranded pieces of deoxyribonucleic corrosive (DNA) and ribonucleic corrosive (RNA) are called DNA probes and RNA probes separately. These DNA and RNA probes are short long (generally 100-1000 bases in length) equipped for framing exceedingly particular, non-covalent duplexes with corresponding grouping of nucleic corrosive strand. In this way, average utilizations of these probes are in fluorescence in situ hybridization (FISH), microarray-based quality articulation profiling or electrophoretic versatility move measures (EMSA).
These DNA and RNA hereditary probes have three essential applications from a medical viewpoint: detection of repeat sequences of mostly 30 to 50 base pairs, detections of alterations in the sequence of nucleic acid, and the detection of specific sequences of nucleic acids. These probes are intended to recognize and distinguish different irresistible specialists, for example, microbes, protozoa and infections. Discovery of hereditary change utilizing DNA and RNA test is likewise of analytic significance in inherited sicknesses, for example, cystic fibrosis, strong dystrophy, phenylketonuria and sickle cell sickliness. The location of pair rehash groupings is of key use in criminological science and paternity testing.
The companies operating in the DNA and RNA probes market are Vysis, Inc., Signet Laboratories, Inc., Sigma-Aldrich Co. LLC., Operon, Inc., Oncor, Inc., Kamiya Biomedical Co., IDEXX Laboratories, Inc., IBA GmbH, Genosys Biotechnologies, Inc., GE Healthcare, FMC Corporation, Epicentre Technologies, and Clontech Laboratories, Inc., and Amersham Life Sciences, Inc.
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Single-stranded fragments of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are called DNA probes and RNA probes respectively. These DNA and RNA probes are short in length (usually 100-1000 bases long) capable of forming highly specific, non-covalent duplexes with complementary sequence of nucleic acid strand. Therefore, typical applications of these probes are in fluorescence in situ hybridization (FISH), microarray-based gene expression profiling or electrophoretic mobility shift assays (EMSA).
These DNA and RNA genetic probes have three important applications from a medical perspective: detection of specific nucleic acid sequences, detection of changes in nucleic acid sequences(mutation) and detection of tandem repeat sequences (30-50 base pairs). These probes are designed to detect and identify various infectious agents such as bacteria, protozoa and viruses. Detection of genetic mutation using DNA and RNA probe is also of diagnostic importance in hereditary diseases such as cystic fibrosis, muscular dystrophy, phenylketonuria and sickle cell anemia. The detection of tandem repeat sequences is of vital use in forensic science and paternity testing.
DNA or RNA probes are categorized either as radioactive probes or as non-radioactive probes based on the nature of material used for labelling. Radioactive probes most commonly involve enzymatic incorporation of 32P, 33P, or 35S. Non-radioactive probesinvolve attaching the probe either to an enzyme (alkaline phosphatase or horseradish peroxidase), an antibody directed against an enzyme, fluorophore, or to an achemifluorescent substrate. Alternatively, these probes can be labeled with biotin, making it detectable by a streptavidin and avidin enzyme conjugate.
Some of the major players in the global DNA and RNA probes market are Amersham Life Sciences, Inc., Clontech Laboratories, Inc., Epicentre Technologies, FMC Corporation, GE Healthcare, Genosys Biotechnologies, Inc., IBA GmbH, IDEXX Laboratories, Inc., Kamiya Biomedical Co., Oncor, Inc., Operon, Inc., Sigma-Aldrich Co. LLC., Signet Laboratories, Inc., and Vysis, Inc.